In this paper, we take the organizational quality-specific immunity of digital technology start-ups as the starting point, and comprehensively use the martin system-TOPSIS research method to evaluate the organizational quality-specific immunity status of digital technology start-ups. The empirical results show that the martin system-TOPSIS method can effectively solve the evaluation and decision-making problem of organizational quality-specific immunity of digital technology start-ups, and the interval number multi-attribute evaluation and decision-making method based on martin system-TOPSIS is effective and feasible in solving the problem of organizational quality-specific immunity evaluation and decision-making of digital technology start-ups.