The major of Fashion and Apparel Design is an applied major, and it is crucial to establish a sound practical teaching system. Currently, there is a lack of large-scale comprehensive training and experimental teaching in this major. This study is based on the background of the development of the clothing industry in the era of big data and the current situation of professional practical teaching. In response to practical course issues, we conducted research on the application of computer-aided technology in clothing design course teaching. Analyze how to start from the current situation of professional teaching, improve students’ design efficiency, strengthen professional practice, and achieve the full process of clothing style from creative design to product sales and operation. To this end, innovative teaching methods for practical courses are proposed, the scope of practice is expanded to enhance students’ hands-on abilities, and a 3D virtual simulation model for analyzing college clothing design teaching assignments is constructed to improve the effectiveness of practical teaching and cultivate high-quality applied clothing professionals.