The droplet contact liquid cooling method can effectively control the battery temperature and temperature difference. However, the cooling performance may be affected by dynamic conditions such as acceleration and road slope. Taking the 18650 lithium-ion battery as the research object, the study focuses on designing a drop contact liquid cooling system targeting power batteries. Additionally, an in-depth study is conducted on the impact of vehicle driving conditions on the heat dissipation performance of the cooling system. Research results indicate that as the drop position offset increases, the heat dissipation performance of the cooling system gradually decreases. Specifically, when the coolant flow rate is 10 mL/ min and the offset reaches 9 mm, the maximum temperature difference of the battery module increases to 3.7°C. Meanwhile, as the slope increases, the heat dissipation performance of the cooling system gradually decreases. When the slope reaches 20% and the coolant flow rate is 20 mL/min, the maximum temperature difference of the battery module is 4.8°C.