Pancake optical systems in virtual reality and augmented reality devices are extremely sensitive to resin lens stress, and stress-induced birefringence can significantly reduce imaging quality. To reduce stress in resin lenses, a multidimensional collaborative control scheme combining optical design optimization, mold design optimization, injection molding process tuning, and annealing treatment is proposed. A conformal 3D waterway mold was designed using Mitsubishi (Epoxy Resin, EP-XR) low stress resin, with optimized injection parameters and combined with 120°C/6h annealing process. Experiments showed that with a balanced injection speed of 50%, a pressure of 45 MPa, a temperature gradient of 105°C between the front and rear molds, and a holding time of 6 s, the residual stress could be controlled at 18.50 nm/mm. The comprehensive optimization plan reduced the residual stress of the lens from 45.20 ± 1.50 nm/mm before optimization to 14.80 ± 0.60 nm/mm, reduced the chromatic aberration to 0.15, increased the light transmittance to 96.5%, and stabilized the shape PV value at 0.25 μm. The proposed multidimensional collaborative control scheme effectively improves the optical quality and structural stability of resin lenses, providing reliable guarantees for high-performance Pancake optical systems.