Tourism e-commerce is a mode of combining e-commerce and tourism industry to realize online transactions in tourism industry. This paper aims to explore the construction and application of tourism e-commerce platform based on cloud computing, firstly analyzing the characteristics and advantages of cloud computing technology, as well as the current situation of the development of tourism e-commerce and the existing problems, and then proposing the architecture and functional modules of the tourism e-commerce platform based on cloud computing, followed by the introduction of the platform’s design methodology and implementation technology, and finally verifying, through examples, the platform’s feasibility and effectiveness, providing a new solution for the digital transformation of the tourism industry.