With the rapid development of science and technology, virtual reality (VR) technology has increasingly become an important tool for global cultural communication. The purpose of this paper is to discuss the application and influence of VR technology in the communication of Chinese and foreign culture. This paper first introduces the basic principle of VR technology and the theoretical framework of cultural communication, and then analyzes the application mode and effect of VR in different cultural backgrounds. By collecting and analyzing usage data from users with different cultural backgrounds, this study established an evaluation model aimed at quantifying the effects of VR technology in cultural communication. The results show that VR technology can significantly improve users’ cultural experience and interactive participation, so as to effectively promote cultural communication and exchange. The study also found that cultural differences and technology acceptance have a significant impact on the communication effectiveness of VR. The findings of this paper provide a new perspective for understanding and optimizing the application of VR technology in global cultural communication, while making suggestions for future development in related fields.